منابع مشابه
Chelators in the Treatment of Iron Accumulation in Parkinson's Disease
Iron is an essential element in the metabolism of all cells. Elevated levels of the metal have been found in the brains of patients of numerous neurodegenerative disorders, including Parkinson's disease (PD). The pathogenesis of PD is largely unknown, although it is thought through studies with experimental models that oxidative stress and dysfunction of brain iron homeostasis, usually a tightl...
متن کاملUsing Iron Chelators - deferasirox in the Treatment of Hypersiderosis
OANA VIOLA BADULESCU1*, MARIA MAGDALENA LEON2*, MADALINA MOCANU1 1 Grigore T. Popa University of Medicine and Pharmacy, Faculty of Medicine, Department of Pathophysiology, 16 Universitatii Str., 700115, Iasi, Romania. 2 Grigore T. Popa University of Medicine and Pharmacy, Faculty of Medicine Iasi, Department of Internal Medicine and Department of Rheumathology, 16 Universitatii Str., 700115, Ia...
متن کاملIron chelators as therapeutic agents for the treatment of cancer.
A wide variety of studies in vitro, in vivo, and in clinical trials have demonstrated that the chelator currently used to treat iron overload disease, desferrioxamine, has anti-proliferative effects against both leukemia and neuroblastoma. However, the efficacy of desferrioxamine is severely limited due to its poor ability to permeate cell membranes and chelate intracellular iron pools. These s...
متن کاملThalassemia: cardiac iron and chelators.
1. Díez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148:293-300. 2. Leth H, Andersen KK, Frystyk J, Tarnow L, Rossing P, Paeving HH, et al. Elevated levels of high-molecularweight adiponectin in type 1 diabetes. J Clin Endocrinol Metab. 2008;93:3186-91. 3. Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Dia...
متن کاملHydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity.
The potentially tridentate ligand 2-pyridinecarbaldehyde isonicotinoyl hydrazone (HPCIH) and its analogues are an emerging class of orally effective Fe chelators that show great promise for the treatment of Fe overload diseases. Herein, we present an extensive study of the Fe coordination chemistry of the HPCIH analogues including the first crystallographically characterised Fe(II) complex of t...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2010
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.99.1267